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Bogdan Razvan Brutiu on Muck Rack

Bogdan Razvan Brutiu

As seen in: BioRxiv
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Articles

A journey towards developing a new cleavable crosslinker reagent for in-cell crosslinking

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By Fraenze Mueller, Iakovos Saridakis, Thomas Leischner, Bogdan Razvan Brutiu
| BioRxiv
Abstract Cross-linking mass spectrometry (XL-MS) is a powerful technology that recently emerged as an essential complementary tool for elucidating protein structures and mapping interactions within a protein network. Crosslinkers which are amenable to post-linking backbone cleavage simplify peptide identification, aid in 3D structure determination and enable system-wide studies of protein-protein interactions (PPIs) in cellular environments.
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