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Bokkyoo Jun

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Articles

Bioavailability and spatial distribution of fatty acids in the rat retina after dietary omega-3 supplementation

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By Elisa Mosler Vidal, Bokkyoo Jun, William Gordon, Marie-Annick Maire
| jlr.org
Bioavailability and spatial distribution of fatty acids in the rat retina after dietary omega-3 supplementation
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Elovanoids are a novel class of homeostatic lipid mediators that protect neural cell integrity upon injury

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By Surjyadipta Bhattacharjee, Bokkyoo Jun, Ludmila Belayev
| Science Magazine Verified
We report the characterization of a novel class of lipid mediators termed elovanoids (ELVs) (ELV-N32 and ELV-N34), which are dihydroxylated derivatives of 32:6n3 and 34:6n3, respectively. The precursors of ELVs are made by elongation of a 22:6n3 fatty acid and catalyzed by ELOVL4 (elongation of very-long-chain fatty acids–4). The structure and stereochemistry of ELVs were established using synthetic compounds produced by stereocontrolled total synthesis.
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