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Articles by Bolin Chen
Single cell multi-omics guided hydrogel enables closed-loop therapy for renal osteodystrophy
Abstract Fracture repair in renal osteodystrophy remains challenging because impaired bone quality compromises fixation stability, while current systemic therapies regulating bone metabolism do not sufficiently address the disease-specific mechanisms underlying defective repair. An integrated strategy combining early fracture stabilization with mechanism-guided local treatment is therefore needed.
A multicenter, clinically interpretable prediction model for malignancy risk in C-TIRADS 3–4 thyroid nodules
Abstract Objectives: To develop and validate clinically interpretable prediction models that integrate ultrasonographic features and laboratory indicators for malignancy risk assessment in thyroid nodules, and to evaluate their potential value in supporting clinical decision-making. Methods: This was a multicenter retrospective study. 631 thyroid nodules from 478 patients at Yueyang People’s Hospital and 193 thyroid nodules from 144 patients at Hunan Cancer Hospital were included.
Privacy-Preserving Anomaly Detection in Cloud Services Using Hierarchical Federated Learning with Differential Privacy
You are already at the latest version Identifying abnormal behaviors plays a vital role in ensuring cloud infrastructure remains secure and operationally stable. Conventional methods that aggregate data at a single location create substantial privacy concerns, especially within shared cloud platforms hosting multiple organizations with confidential operational information.
Precedent-Informed Reasoning: Mitigating Overthinking in Large Reasoning Models via Test-Time Precedent Learning
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Severity and Phenotype of Sleep-Disordered Breathing in Prader-Willi Syndrome Compared to Obstructive Sleep Apnea Syndrome in Children
Keywords Prader-Willi syndrome Obstructive sleep apnea-hypopnea syndrome Children Polysomnography BMI Get full text access Log in, subscribe or purchase for full access. Reference 1. Ingram, D.G. ∙ Arganbright, J.M. ∙ Paprocki, E. ... Sleep disorders in children with prader Willi syndrome: current perspectives Nature and Science of Sleep. 2022; 14:2065-2074 2. Gillett, E.S. ∙ Perez, I.A. Disorders of sleep and ventilatory control in prader-willi syndrome Diseases. 2016; 4:23 3.
Deep Learning-Based Uncertainty-Driven Robust Time Series Forecasting for Backend Service Metrics
Submitted: 28 January 2026 You are already at the latest version This study addresses the challenge of forecasting backend service metrics in highly dynamic and disturbed environments and proposes a robust time series prediction framework based on uncertainty estimation. The method first applies a multi-scale encoding structure to decompose and represent service metric sequences, allowing the model to capture mixed characteristics of trends, periodic patterns, and noise disturbances.
Deep GraphRAG: A Balanced Approach to Hierarchical Retrieval and Adaptive Integration
arXivLabs is a framework that allows collaborators to develop and share new arXiv features directly on our website. Both individuals and organizations that work with arXivLabs have embraced and accepted our values of openness, community, excellence, and user data privacy. arXiv is committed to these values and only works with partners that adhere to them. Have an idea for a project that will add value for arXiv's community? Learn more about arXivLabs.
Faithfulness-Aware Multi-Objective Context Ranking for Retrieval-Augmented Generation
Submitted: 20 December 2025 You are already at the latest version Retrieval-Augmented Generation (RAG) has emerged as a dominant paradigm for enhancing Large Language Models (LLMs) with external knowledge. However, existing ranking methods in RAG pipelines primarily optimize for document-query relevance, neglecting crucial factors for generation quality such as factual consistency and information coverage.
FlashServe: Cost-Efficient Serverless Inference Scheduling for Large Language Models via Tiered Memory Management and Predictive Autoscaling
Submitted: 21 December 2025 You are already at the latest version Deploying Large Language Models (LLMs) in cloud environments presents significant challenges due to their substantial memory footprint and computational requirements. While serverless architectures offer attractive pay-per-use economics, they suffer from prohibitively long cold start times when loading multi-gigabyte model weights into GPU memory.
Positive Correlation Between Economic Activities and Fish Diversity in Small River Basins of Less Developed Regions
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The Extract of Camellia Seed Cake Alleviates Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) in Mice by Promoting Coenzyme Q Synthesis
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Identifying Cancer Stage-Related Biomarkers for Lung Adenocarcinoma by Integrating Both Node and Edge Features
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Illuminating cisplatin-induced ferroptosis in non-small-cell lung cancer with biothiol-activatable fluorescent/photoacoustic bimodal probes
Illuminating cisplatin-induced ferroptosis in non-small-cell lung cancer with biothiol-activatable fluorescent/photoacoustic bimodal probes† Ferroptosis modulation represents a pioneering therapeutic approach for non-small-cell lung cancer (NSCLC), where precise monitoring and regulation of ferroptosis levels are pivotal for achieving optimal therapeutic outcomes.
Milling Cutter Wear State Identification Method Based on Improved ResNet-34 Algorithm
1. Introduction Tool wear is a naturally occurring phenomenon during cutting and machining, caused by the interaction of unavoidable chemical, mechanical, and physical factors. If this problem is not diagnosed and addressed promptly, it may lead to abnormal cutting conditions, potentially affecting machining efficiency and quality in serious cases [1,2]. Implementing an effective tool condition monitoring system can improve surface quality, increase productivity, and reduce machining costs.
Dynamic Personalized Recipe Recommendations Based on Facial Health Recognition
1. Introduction In recent years, with the continuous improvement of life quality, individuals’ dietary requirements and health awareness have undergone positive changes. Personalized recipes are highly favored compared with traditional universal recipes, as they cater to individual dietary preferences and incorporate considerations for improving individuals’ overall health.
Hypocretenolide: Collective Total Syntheses and Its Activities toward Metastatic Colon Cancer
Hypocretenolide: Collective Total Syntheses and Its Activities toward Metastatic Colon Cancer A concise and collective synthetic route to hypocretenolides was developed for the first time. This route features the one-pot addition-alkylation and intramolecular 1,3-dipolar cycloaddition to efficiently assemble the 5/7/6 ring system. Our syntheses enabled multigram preparation of hypocretenolide which facilitated further biological evaluation.
Virgin Camellia Seed Oil Improves Glycolipid Metabolism in the Kidney of High Fat-Fed Rats through AMPK-SREBP Pathway
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Total Syntheses of Brassicicenes A, R, and T
CCDC 2268186 and 2295027 contain the supplementary crystallographic data for this paper. These data can be obtained free of charge via www.ccdc.cam.ac.uk/data_request/cif, or by emailing data_request@ccdc.cam.ac.uk, or by contacting The Cambridge Crystallographic Data Centre, 12 Union Road, Cambridge CB2 1EZ, UK; fax: +44 1223 336033. Terms & Conditions Most electronic Supporting Information files are available without a subscription to ACS Web Editions.
Total Syntheses of Brassicicenes A, R, and T
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Optimization of the Ginkgo Wine Fermentation Process and Influence of Fermentation Starter Types on the Brewing Flavor
3.4. Comparison Analysis of Volatile Components in Fermented Ginkgo Wine shows the percentage contents of volatile compounds in the white nut enzymatic hydrolysate, including seven aldehydes, three alcohols, two esters, and one hydrocarbon. The compound with the highest volatile component content was pentadecanal, accounting for 17.45% of the 18 compounds, followed by n-hexanal at 14.1%.
A Two‐Phase Approach to Fusicoccane Synthesis To Uncover a Compound That Reduces Tumourigenesis in Pancreatic Cancer Cells
Research Article Bolin Chen, Bolin Chen State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy, Nankai University, 38 Tongyan Road, Tianjin, 300353 P. R. China Search for more papers by this author Qianwei Wu, Qianwei Wu State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy, Nankai University, 38 Tongyan Road, Tianjin, 300353 P. R.
Total Synthesis of Isorosthin L and Isoadenolin I
Communication Junli Ao, Junli Ao orcid.org/0000-0002-2437-6059 State Key Laboratory of Elemento-organic Chemistry, College of Chemistry, Nankai University, Tianjin, 300071 China School of Physical Science and Technology, ShanghaiTech University, Shanghai, 201210 China Search for more papers by this author Chao Sun, Chao Sun School of Physical Science and Technology, ShanghaiTech University, Shanghai, 201210 China Search for more papers by this author Bolin Chen, Bolin Chen State Key...
Ethnicity associations with food sensitization are mediated by gut microbiota development in the first year of life
This paper is only available as a PDF. To read, Please Download here. Abstract Background and aims Increasing evidence supports the role of early-life gut microbiota in developing atopic diseases, but ecological changes to gut microbiota during infancy in relation to food sensitization remain unclear. We aimed to characterize and associate these changes with the development of food sensitization in children.
linking academia, business and industry through research
Home Full-text access for editors A functional network construction method to interpret the pathological process of colorectal cancer by Bolin Chen; Manting Yang; Li Gao; Tao Jiang; Xuequn Shang International Journal of Data Mining and Bioinformatics (IJDMB), Vol. 23, No. 3, 2020 Abstract: The prognosis of cancers remains a challenge due to the limited understanding of their pathogenic mechanisms and cancerous processes.
High Aspect Ratio, Carbon Nanotube Membranes Decorated with Pt Nanoparticle Urchins for Micro Underwater Vehicle Propulsion via H2O2 Decomposition
Home > Faculty Publications > 2974 Authors Kevin M. Marr Bolin Chen Eric J. Mootz Jason Geder Marius Pruessner Brian J. Melde Richard R. Vanfleet Igor L. Medintz Brian D. Iverson, Brigham Young University - ProvoFollow Jonathan C.
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