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Bonpei Takase

As seen in: Wiley Online Library
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Articles

Liposome‐encapsulated hemoglobin rescues hemorrhagic shock heart through anti‐ischemic and anti‐arrhythmogenic effects on myocardium in repetitive 65% bleeding rat model

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By Bonpei Takase, Yuko Higashimura, Nobuyuki Masaki, Manabu Kinoshita
| Wiley Online Library Verified
Background Phase I clinical trial of an artificial oxygen carrier (liposome-encapsulated hemoglobin vesicles [HbVs]) is safely completed, considering the other clinical application. Herein, we aimed to investigate the resuscitation effects of HbVs in cases of lethal hemorrhage, including the mechanisms involved.
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Intraosseous infusion of liposome‐encapsulated hemoglobin (HbV) acutely prevents hemorrhagic anemia‐induced lethal arrhythmias and its efficacy persists with preventing proarrhythmic side effects in subacute phase of severe hemodilution model

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By Bonpei Takase, Yuko Higashimura, Haruka Asahina, Nobuyuki Masaki
| Wiley Online Library Verified
MAIN TEXT Bonpei Takase, Corresponding Author Bonpei Takase dui1577@db3.so-net.ne.jp orcid.org/0000-0002-7889-6260 Department of Intensive Care Medicine, National Defense Medical College, Tokorozawa, Saitama, Japan Correspondence Bonpei Takase, MD, National Defense Medical College, Department of Intensive Care Medicine, 3-2 Namiki, Tokorozawa, Saitama 359-8513, Japan, Tel.: +81-4-2995-1211, Fax: +81-4-2991-1611 E-mail: dui1577@db3.so-net.ne.jp Search for more papers by this author Yuko...
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Liposome‐encapsulated hemoglobin (HbV) transfusion rescues rats undergoing progressive lethal 85% hemorrhage as a result of an anti‐arrhythmogenic effect on the myocardium

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By Bonpei Takase, Masayuki Ishihara, Yuko Higashimura, Haruka Asahina
| Wiley Online Library Verified
MAIN TEXT Bonpei Takase, Corresponding Author dui1577@db3.so-net.ne.jp orcid.org/0000-0002-7889-6260 Department of Intensive Care Medicine, National Defense Medical College, Japan Correspondence Bonpei Takase, MD, National Defense Medical College, Department of Intensive Care Medicine, 3-2 Namiki, Tokorozawa, Saitama 359-8513, Japan E-mail: dui1577@db3.so-net.ne.jp Search for more papers by this author Yuko Higashimura, Department of Intensive Care Medicine, National Defense Medical College,...
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