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Booshini Fernando

As seen in: BioRxiv
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Articles

Function-specific epistasis shapes evolutionary trajectories towards antibiotic resistance

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By Gerrit Ansmann, Gabriela Petrungaro, Theresa Fink, Booshini Fernando
| BioRxiv
Abstract Pre-existing mutations can create contingencies that influence subsequent evolution by constraining or opening evolutionary pathways through epistatic interactions. In some cases, global epistasis allows evolutionary pathways to be predicted from the fitness of the genetic background alone. In other cases idiosyncratic epistasis makes evolution less predictable.
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