Boris Rafael Gueorguiev on Muck Rack

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Articles

Repeated low-intensity focused ultrasound led to microglial profile changes at long term in TgF344-AD rats

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By Anthony Novell, Benoit Larrat, Laurene Abjean, Boris Rafael Gueorguiev
| biorxiv.org
Abstract Alzheimer′s disease (AD), the most common cause of dementia, represents one of the main clinical challenges of the century as the number of patients is predicted to triple by 2050. Despite the recent approval of three monoclonal antibodies targeting Amyloid β (Aβ) aggregates by the Food and Drug Administration (FDA), immunotherapies still face challenges due to the difficulty of antibodies crossing the blood-brain barrier (BBB).
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