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Boris Zühlke on Muck Rack

Boris Zühlke

As seen in: Stem Cell Reports
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Articles

SARS-CoV-2 tropism to intestinal but not gastric epithelial cells is defined by limited ACE2 expression

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By Diana Fatykhova, Humboldt-Universität zu Berlin, Boris Zühlke, Technische Universität Berlin
| Stem Cell Reports Verified
Highlights • SARS-CoV-2 robustly infects intestinal, but not gastric, organoid-derived monolayers • The infection tropism is matched by ACE2 expression in organoid-derived monolayers • Ectopic expression of ACE2 indicates that ACE2 is the limiting factor • Histology confirms the ACE2 expression pattern also in patient tissues Summary Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection primarily affects the lung but can also cause gastrointestinal (GI) symptoms.
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