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Structure of the NAT10 acetyltransferase and mechanism of tRNA acetylation
Abstract NAT10 is the sole eukaryotic acetyltransferase that catalyzes N4-acetylcytidine (ac4C) modification of RNA. While dysregulation of NAT10 is associated with cancer and premature aging syndromes, the requirement for its acetyltransferase activity and how NAT10 coordinates catalysis and RNA binding remain poorly understood.
Inert Heteroatom Substitution to Modulate Dual‐Metal‐Sites for Boosting Photoreduction of Diluted CO2
Conflict of Interest The authors declare no conflict of interest. Supporting Information Filename Description adfm202503764-sup-0001-SuppMat.docx6.6 MB Supporting Information References 1, , , , , , Chem. Soc. Rev. 2020, 49, 6592. 2, , , , , , , , , , Nat. Commun. 2022, 13, 4681. 3, , , , , Acc. Chem. Res. 2023, 56, 2500. 4, , , , , , , , , , , , , Angew. Chem., Int. Ed. 2023, 62, 202301075. 5, , , , , , Nat. Commun. 2024, 15, 4807. 6, , , , Nat. Commun. 2019, 10, 443. 7, , , , , , , , , Angew. Chem., Int.
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