Bradley Lockwood

Immunodominance of Antibody Recognition of the HIV Envelope V2 Region in Ig-Humanized Mice Kevin Wiehe, Nathan I. Nicely, Bradley Lockwood, Masayuki Kuraoka, Kara Anasti, Sabrina Arora, Cindy M. Bowman, Christina Stolarchuk, Robert Parks, Krissey E. Lloyd, Shi-Mao Xia, Ryan Duffy, Xiaoying Shen, Christos A. Kyratsous, Lynn E. Macdonald, Andrew J. Murphy, Richard M. Scearce, M. Anthony Moody, S. Munir Alam, Laurent Verkoczy, Georgia D. Tomaras, Garnett Kelsoe, Barton F.

In the RV144 gp120 HIV vaccine trial, decreased transmission risk was correlated with Abs that reacted with a linear epitope at a lysine residue at position 169 (K169) in the HIV-1 envelope (Env) V2 region. The K169 V2 response was restricted to Abs bearing V? rearrangements that expressed aspartic acid/glutamic acid in CDR L2. The AE.A244 gp120 in AIDSVAX B/E also bound to the unmutated ancestor of a V2-glycan broadly neutralizing Ab, but this Ab type was not induced in the RV144 trial.