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Highlights • The self-polymerizing HIV-1 capsid protein ‘trapped’ in discrete, soluble oligomers • Engineered capsid protein assemblies faithfully mimic the infectious capsid surface • Host factors MxB, TRIMCyp, TRIM5α, and FEZ1 recognize unique capsid patterns • Capsid binding by proteins and small molecules can be rapidly analyzed Summary The HIV-1 capsid is an ordered protein shell that houses the viral genome during early infection.
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