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Brahmmi Patel

As seen in: BioRxiv
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Articles

Phase Separation Oppositely Modulates G-quadruplex and i-Motif DNA Folding in the Nuclei of Living Cells

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By Hyejin Yoo, Caitlin Davis, Brahmmi Patel, Cailin Hoang
| BioRxiv
Abstract G-quadruplexes and i-motifs are non-canonical DNA structures that are thought to play an important role in the regulation of gene expression. Although these structures have been well studied in vitro, they are often characterized in non-physiological buffers intended to stabilize their structure. Therefore, additional work is necessary to understand how the cellular environment promotes their folding.
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