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Brandon Hubbard on Muck Rack

Brandon Hubbard

As seen in: Nature, Cell Metabolism
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Articles

Insulin receptor T1160 phosphorylation mediates renal cortical insulin resistance but not excess gluconeogenesis from glycerol

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By Brandon Hubbard, Yumin Ma, Rafael C. Gaspar, Traci E. LaMoia, Dongyan Zhang, Mario Kahn, Sylvie Dufour, Ali R. Nasiri, Gerald I. Shulman
| Nature Verified
Abstract Impaired suppression of endogenous glucose production (EGP) drives end-organ damage in insulin resistance and type 2 diabetes. Although the liver is traditionally thought to mediate dysregulated EGP, the role of the renal cortex is less understood. Here, we investigate if high-fat diet (HFD) induces renal cortical insulin resistance while assessing renal glucose production (RGP) and mitochondrial metabolism in male mice.
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Q-Flux: A method to assess hepatic mitochondrial succinate dehydrogenase, methylmalonyl-CoA mutase, and glutaminase fluxes in vivo

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By Brandon Hubbard, Traci E. LaMoia, Leigh Goedeke, Rafael C. Gaspar
| Cell Metabolism Verified
Hasenour C.M. Wall M.L. Ridley D.E. Hughey C.C. James F.D. Wasserman D.H. Young J.D. Mass spectrometry-based microassay of 2H and 13C plasma glucose labeling to quantify liver metabolic fluxes in vivo. Am. J. Physiol. Endocrinol. Metab. 2015; 309: E191-E203 Jin E.S. Jones J.G. Merritt M. Burgess S.C. Malloy C.R. Sherry A.D. Glucose production, gluconeogenesis, and hepatic tricarboxylic acid cycle fluxes measured by nuclear magnetic resonance analysis of a single glucose derivative. Anal. Biochem.
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