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iHALT unlocks liver functionality as a surrogate secondary lymphoid organ - Nature

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By John Gridley, David Pak, Anuradha Kumari, Brantley Holland, Yifeng Shi, Amit Kapoor, Jacob Shupak
| Nature Verified
Abstract Upon viral infection, the current paradigm of humoral immunity posits that germinal centre reactions occurring within secondary lymphoid organs (SLOs) yield effector plasma cells that subsequently traffic to infected organs or the bone marrow1,2,3. However, it is not well understood how viral tissue tropism may govern the spatiotemporal dynamics of such responses.
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