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Braulio Carrillo Sanchez

As seen in: Wiley Online Library
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Articles

Enhancing Adeno-Associated Virus 2 Capsid Engineering Through Co-Evolutionary Coupling

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By Yiwen Li, Braulio Carrillo Sanchez, Sirimar Laosinwattana
| Wiley Online Library Verified
1 Introduction In gene therapy, vectors are essential to deliver the transgene to the target cells. The most prominent viral vectors are lentiviruses, adenoviruses (Ads), and adeno-associated viruses (AAVs) (Bulcha et al. 2021; Srivastava et al. 2021).
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Chinese hamster ovary cell line engineering strategies for modular production of custom extracellular vesicles

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By Mark Ellis, Catherine Simpson, Braulio Carrillo Sanchez, Matthew Hinchliffe
| Wiley Online Library Verified
1 INTRODUCTION Extracellular vesicles (EVs) present a promising therapeutic platform for the delivery of bioactive cargo owing to their central role in intercellular communication. Produced and naturally secreted by mammalian cells, EVs are lipid bilayer structures packed with functional protein, lipid and nucleic acid cargoes, which are exchanged between cells (Mulcahy et al., 2014; Van Niel et al., 2018).
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