Braxten D Hornsby

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Protein oligomerization is pivotal for a diverse range of cellular processes, including signal transduction, gene expression, enzyme activity and regulation, and protein binding. (1−14) Such processes reflect but a fraction of the complete human interactome, composed of an estimated 650,000 unique protein–protein interactions (PPIs) responsible for regulating physiological functions. (15) Consequently, dysregulation within the interactome is also responsible for the development of disease states.