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Modulatory Role of Nitric Oxide on the Vasomotor Actions of NPY in Porcine Cerebral Arteries
1 Introduction In the brain, pial arteries are innervated extrinsically by sympathetic nerves that release the vasoactive neurotransmitters adenosine triphosphate, norepinephrine, and neuropeptide-Y (NPY) [1]. NPY elicits vasoconstriction via Y1 peptidergic receptors located on the vascular smooth muscle and potentiates vasoconstriction induced by adenosine triphosphate or norepinephrine [1-4].
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