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Bree M Lege

As seen in: Nature, Texas Medical Center
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Articles by Bree M Lege

Extracellular matrix mediates circulating tumor cell clustering in triple-negative breast cancer metastasis - Nature Communications

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By Khushali Patel, Bree M Lege, Gad Shaulsky, Georg OM Bobkov
| Nature Verified
Abstract Metastatic tumor cell dissemination is the leading cause of cancer-related deaths. Clustered circulating tumor cells (CTCs) possess higher metastatic potential than single CTCs. Epithelial adherens junction (AJ) proteins typically mediate stable cell-cell interactions; however, these proteins are frequently lost in highly aggressive triple-negative breast cancers (TNBCs), raising the question of how CTCs from such tumors cluster.
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Surface Marker Identification to Capture Live Circulating Tumor Cells in Metastatic Triple-Negative Breast Cancer

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By Bree M Lege
| Texas Medical Center
Cancer Research Communications 10.1158/2767-9764.CRC-25-0536 Post-print Neoplastic Cells, Circulating, Triple Negative Breast Neoplasms, Animals, Humans, Female, Biomarkers, Tumor, Mice, Single-Cell Analysis, Cell Line, Tumor, Neoplasm Metastasis yes Lege, Bree M; Patel, Khushali J; Panici, Brendan; et al., "Surface Marker Identification to Capture Live Circulating Tumor Cells in Metastatic Triple-Negative Breast Cancer" (2026). Faculty, Staff and Students Publications. 6388.
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