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Georg OM Bobkov on Muck Rack

Georg OM Bobkov

As seen in: Nature, Texas Medical Center
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Articles

Extracellular Matrix Mediates Circulating Tumor Cell Clustering in Triple-Negative Breast Cancer Metastasis

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By Georg OM Bobkov
| Texas Medical Center
Publication Date 2-6-2026 Journal Nature Communications DOI 10.1038/s41467-026-69007-w PubMedCentral® Posted Date 2-6-2026 PubMedCentral® Full Text Version Post-print Abstract Metastatic tumor cell dissemination is the leading cause of cancer-related deaths.
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Extracellular matrix mediates circulating tumor cell clustering in triple-negative breast cancer metastasis - Nature Communications

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By Khushali Patel, Bree M Lege, Gad Shaulsky, Georg OM Bobkov
| Nature Verified
Abstract Metastatic tumor cell dissemination is the leading cause of cancer-related deaths. Clustered circulating tumor cells (CTCs) possess higher metastatic potential than single CTCs. Epithelial adherens junction (AJ) proteins typically mediate stable cell-cell interactions; however, these proteins are frequently lost in highly aggressive triple-negative breast cancers (TNBCs), raising the question of how CTCs from such tumors cluster.
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