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Briah Barksdale on Muck Rack

Briah Barksdale

As seen in: Nature, BioRxiv
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Articles

Interleukin-27 is antiviral against Zika virus at the maternal-fetal interface - Nature Communications

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By Madeline S. Merlino, Briah Barksdale, Rebecca Clements, Christopher Hunter
| Nature Verified
Abstract Congenital viral infections can have severe consequences for pregnancy and fetal outcomes. Remarkably, the fetal-derived placenta serves as a robust barrier to infection through meticulous regulation by immune effectors and cytokines. Yet, the regulatory roles of many cytokines remain undefined at the maternal-fetal interface, including Interleukin-27 (IL-27).
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Interleukin-27 is antiviral at the maternal-fetal interface.

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By Madeline S. Merlino, Seble G Negatu, Rebecca Clements, Briah Barksdale
| BioRxiv
Abstract Congenital viral infections can have severe consequences for pregnancy and fetal outcomes. Remarkably, the fetal-derived placenta serves as a robust barrier to infection through meticulous regulation by immune effectors and a diverse repertoire of cytokines. Yet, the regulatory roles of many cytokines remain undefined at the maternal-fetal interface. Interleukin 27 (IL-27) is a highly expressed cytokine in the placenta whose functional consequence during congenital infection is unknown.
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