Brian David Dynlacht on Muck Rack

Brian David Dynlacht

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Articles

Identification of a component of the tubulin poly-glutamylase complex required for phosphoinositide homeostasis and cilium assembly and maintenance

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By Binshad Badarudeen, Loren Collado, Hung-Ju Chiang, Lei Wang, Irma Sánchez, Brian David Dynlacht
| Nature Verified
Abstract The tubulin poly-glutamylase complex (TPGC) is comprised of TTLL1 and at least five associated proteins that promote the addition of glutamate residues to carboxy-terminal tails of tubulin subunits comprising microtubules. Despite its discovery two decades ago, the enzyme has been refractory to characterization owing to its complex multimeric nature and the inability to detect poly-glutamylase activity after assembling the six-subunit complex.
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By Wenxiang Fu, Sehyun Kim, Ji Li, Brian David Dynlacht
| secure.jbs.elsevierhealth.com
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