By Joshua L. Bacon, DO, and Brian Patrick Murray, DO Withdrawal syndromes are common, high-acuity presentations in the emergency department (ED), arising after abrupt cessation or reduction of chronically used substances. They range from mild discomfort to life-threatening complications, such as seizures, delirium tremens, or severe autonomic instability. Alcohol, opioids, benzodiazepines/barbiturates, and antidepressants constitute the majority of withdrawal-related ED visits.