Brian Pogue

1. Introduction Understanding tissue oxygen content, especially the lack of oxygen, is key for assessing proper tissue function. Of special interest are tumors, which often grow with chaotic neo-vasculature, subsequently creating both chronic and transient hypoxia conditions.

1. Introduction Medical devices used in patient care have many forms, ranging all the way from multi-million-dollar imaging systems to guide interventional procedures, to pocket-sized diagnostic systems that cost a few hundred dollars. The major tools developed for imaging or intervention fall into two very broad categories, which can be roughly categorized as radiologic systems or optical systems.

S. Niu, Q. Zhu, Y. Jiang, J. Zhu, M. Xiao, S. You, W. Zhou, and Y. Xiao, “Correlations among ultrasound-guided diffuse optical tomography, microvessel density, and breast cancer prognosis,” J Ultrasound Med 37(4), 833–842 (2018). [Crossref] J. Feng, Sh. Jiang, B. Pogue, and P. Keith, “Weighting function effects in a direct regularization method for image-guided near- infrared spectral tomography of breast cancer,” Biomed. Opt. Express 9(7), 3266–3283 (2018). [Crossref] E. A. Lim, J. E. Gunther, H. K. Kim, M.