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Bridget Marie Barker on Muck Rack

Bridget Marie Barker

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Factor Xa cleaves SARS-CoV-2 spike protein to block viral entry and infection - Nature Communications

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By Erik Settles, Pinghui Feng, Weiming Yuan, Paul Keim, Michael Caligiuri, Bridget Marie Barker
| Nature Verified
Abstract Serine proteases (SP), including furin, trypsin, and TMPRSS2 cleave the SARS-CoV-2 spike (S) protein, enabling the virus to enter cells. Here, we show that factor (F) Xa, an SP involved in blood coagulation, is upregulated in COVID-19 patients. In contrast to other SPs, FXa exerts antiviral activity. Mechanistically, FXa cleaves S protein, preventing its binding to ACE2, and thus blocking viral entry and infection.
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