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Bridgette A. Barry on Muck Rack

Bridgette A. Barry

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Articles

Specific metallo-protein interactions and antimicrobial activity in Histatin-5, an intrinsically disordered salivary peptide

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By Tyler G. McCaslin, Cynthia V. Pagba, Bridgette A. Barry, Jiby Yohannan
| Nature Verified
Abstract Histatin-5 (Hst-5) is an antimicrobial, salivary protein that is involved in the host defense system. Hst-5 has been proposed to bind functionally relevant zinc and copper but presents challenges in structural studies due to its disordered conformation in aqueous solution. Here, we used circular dichroism (CD) and UV resonance Raman (UVRR) spectroscopy to define metallo-Hst-5 interactions in aqueous solution.
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