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Functional screening of TCR-like antibodies using STAR-T cell library for cancer immunotherapy

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By Changping Laboratory, BriStar Immunotech
| link.springer.com
Cognate antigen triggers STAR endocytosis and activation of STAR-T cells in an antigen-specific manner STAR is a synthetic double-chain TCR-based chimeric receptor, which combines the antigen-recognition domain of antibody with constant regions of TCR that engage endogenous CD3 signaling machinery. Based on our previous works, STARs exhibit lower tonic signaling and higher sensitivity than conventional CARs (Fig. EV1A) (Burton et al, 2023; Huang et al, 2024; Liu et al, 2021b; Wang et al, 2022).
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