Brita Singers Sørensen

Abstract Syngeneic mouse models are widely used to study immune-mediated tumor responses. While these models are typically implanted in the flank of the mouse, some experimental setups require alternative sites of tumor implantation, such as the foot. It remains unclear how tumors in the flank and the foot differ in terms of immune cell infiltration, thus introducing an unresolved variable in the interpretation of studies applying these two distinct models.

Abstract Preclinical studies have shown a preferential normal tissue sparing effect of FLASH radiotherapy with ultra-high dose rates. The aim of the present study was to use a murine model of acute skin toxicity to investigate the biological effect of varying dose rates, time structure, and of introducing pauses in the dose delivery.