ResearchGastroenterologyNeuroscience Open Access | 10.1172/jci.insight.199820 JCI Insight. https://doi.org/10.1172/jci.insight.199820. Copyright © 2026, Obidike et al. This work is licensed under the Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. View PDF Abstract Hirschsprung disease (HSCR) is a congenital intestinal disorder characterized by the absence of ganglia in the distal intestine.