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Britta Bartelt-Kirbach on Muck Rack

Britta Bartelt-Kirbach

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HspB5/αB‐crystallin phosphorylation at S45 and S59 is essential for protection of the dendritic tree of rat hippocampal neurons

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By Christoph Wiegreffe, Samuel Birk, Tina Baur, Britta Bartelt-Kirbach
| Wiley Online Library Verified
Abstract Rarefaction of the dendritic tree leading to neuronal dysfunction is a hallmark of many neurodegenerative diseases and we have shown previously that heat shock protein B5 (HspB5)/αB-crystallin is able to increase dendritic complexity in vitro. The aim of this study was to investigate if this effect is also present in vivo, if HspB5 can counteract dendritic rarefaction under pathophysiological conditions and the impact of phosphorylation of HspB5 in this process.
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