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Brooke M Seman

As seen in: Nature, BioRxiv
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Articles

Cryptic variation fuels plant phenotypic change through hierarchical epistasis - Nature

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By Sophia G. Zebell, Michael Lach, Brooke M Seman, Anat Hendelman, Simon Sretenovic, Yuval Eshed, David M. McCandlish
| Nature Verified
Abstract Cryptic genetic variants exert minimal phenotypic effects alone but are hypothesized to form a vast reservoir of genetic diversity driving trait evolvability through epistatic interactions1,2,3. This classical theory has been reinvigorated by pan-genomics, which is revealing pervasive variation within gene families, cis-regulatory regions and regulatory networks4,5,6.
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Cryptic variation fuels plant phenotypic change through hierarchical epistasis

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By Sophia G. Zebell, Blaine Fitzgerald, Michael Lach, Brooke M Seman
| BioRxiv
Abstract Cryptic genetic variants exert minimal or no phenotypic effects alone but have long been hypothesized to form a vast, hidden reservoir of genetic diversity that drives trait evolvability through epistatic interactions. This classical theory has been reinvigorated by pan-genome sequencing, which has revealed pervasive variation within gene families and regulatory networks, including extensive cis-regulatory changes, gene duplication, and divergence between paralogs.
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