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Bruk Mensa

As seen in: Nature, Royal Society of Chemistry
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Articles

Spiers Memorial Lecture: Analysis and de novo design of membrane-interactive peptides

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By Huong T. Kratochvil, Bruk Mensa, Marco Mravic
| Royal Society of Chemistry Verified
Spiers Memorial Lecture: Analysis and de novo design of membrane-interactive peptides Huong T. Kratochvil, *a Robert W. Newberry, †*a Bruk Mensa, a Marco Mravic b and William F.
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SNAC-tag for sequence-specific chemical protein cleavage - Nature Methods

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By Marco Mravic, Hailin Hu, Nathan Schmidt Verified, Bruk Mensa
| Nature Verified
Abstract Site-specific protein cleavage is essential for many protein-production protocols and typically requires proteases. We report the development of a chemical protein-cleavage method that is achieved through the use of a sequence-specific nickel-assisted cleavage (SNAC)-tag.
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Structure and Function of the Transmembrane Domain of NsaS, an Antibiotic Sensing Histidine Kinase in Staphylococcus aureus

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By Thomas Lemmin, Georg Kuenze, Soumya Ganguly, Bruk Mensa
| American Chemical Society
NsaS is one of four intramembrane histidine kinases (HKs) in Staphylococcus aureus that mediate the pathogen’s response to membrane active antimicrobials and human innate immunity. We describe the first integrative structural study of NsaS using a combination of solution state NMR spectroscopy, chemical-cross-linking, molecular modeling and dynamics.
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