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Articles

miR-135a Inhibits the Invasion of Cancer Cells via Suppression of ERRα

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By Universite de Lyon, Violaine Tribollet, Bruno Barenton, Auriane Kroiss
| PLOS
MicroRNA-135a (miR-135a) down-modulates parameters of cancer progression and its expression is decreased in metastatic breast cancers (as compared to non-metastatic tumors) as well as in prostate tumors relative to normal tissue. These expression and activity patterns are opposite to those of the Estrogen-Related Receptor α (ERRα), an orphan member of the nuclear receptor family.
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