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234. Low-Intensity Focused Ultrasound (FUS) Amygdala Neuromodulation: An fMRI Target Engagement Study and Open-Label Treatment Trial in Mixed Mood, Anxiety, and Trauma-Related Disorders
Affective disorders (ADs), i.e. mood, anxiety, and trauma-related disorders, show common amygdala (AMYG) hyperactivity to emotional cues. Low-intensity focused ultrasound (FUS) can modulate brain function in subcortical areas. Here, using concurrent FUS/functional magnetic resonance imaging (fMRI), we tested FUS modulation of the left AMYG in AD patients (N=23) and healthy controls (HCs)(N=23).
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