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Cohousing of Il10?/? with Il10?/?Nlrp6?/? Mice Does Not Result in Transfer of Colitis Susceptibility Increased Colonization of A. muciniphila Is Sufficient to Trigger Significant Colitis in Il10?/? Mice Previous studies suggested that Nlrp6?/? mice have increased levels of Prevotella and TM7 compared to WT mice (Elinav et al., 2011xNLRP6 inflammasome regulates colonic microbial ecology and risk for colitis.
Ulcerative colitis (UC) is an inflammatory bowel disease (IBD) that involves chronic inflammation involving the colon. We have previously shown that NLRP6 protects against the development of chemically-induced colitis. Here, we demonstrate that NLRP6 is important for suppressing the development of spontaneous colitis in the IL-10−/− mice model of IBD.
NLRP6 is a member of the Nod-like receptor (NLR) family, whose members are involved in the recognition of microbes and/or tissue injury. NLRP6 was previously shown to regulate IL-18 secretion and is important for protecting mice against chemically-induced colitis and colitis-associated colon cancer. However, the cellular mechanisms by which NLRP6 reduces susceptibility to colonic inflammation remain unclear.
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