Bryce E Duffett

Editor’s summary Abstract Supplementary Materials REFERENCES AND NOTES Information & Authors Metrics & Citations Check Access References Figures Tables Media Share Editor’s summary Despite being an autoimmune disease, type 1 diabetes (T1D) is not solely driven by the adaptive immune response. Rather, insulin-producing β cells themselves can mount inflammatory responses and respond to stressors. Here, Wagner et al.

Editor’s summary Abstract Supplementary Materials REFERENCES AND NOTES Information & Authors Metrics & Citations Check Access References Figures Tables Media Share Editor’s summary Dysfunctional autophagy in β cells is a feature of type 1 diabetes (T1D); however, because this is a dynamic process, it is difficult to characterize by evaluating only a single time point. Here, Melnyk et al.

Abstract Type 1 diabetes (T1D) is a multifactorial disease involving genetic and environmental factors, including viral infection. We investigated the impact of interferon alpha (IFN-α), a cytokine produced during the immune response to viral infection or the presence of un-edited endogenous double-stranded RNAs, on human β-cell physiology.