Bryce M Timm on Muck Rack

Bryce M Timm

As seen in: BioRxiv
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Articles

Human Sulfatases Use Dual Mechanisms to Control Growth Factor–Heparan Sulfate Interactions Click to copy article link Article link copied!

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By Bryce M Timm, Julianna L Follmar, Ryan N. Porell
| dx.doi.org
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Human extracellular sulfatases use a dual mechanism for regulation of growth factor interactions with heparan sulfate proteoglycans

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By Ryan N. Porell, Kimberly Glass, Bryce M Timm, Julianna L Follmar
| BioRxiv
Abstract Membrane-associated heparan sulfate (HS) proteoglycans (PGs) contribute to the regulation of extracellular cellular signaling cues, such as growth factors (GFs) and chemokines, essential for normal organismal functions and implicated in various pathophysiologies. PGs accomplish this by presenting high affinity binding sites for GFs and their receptors through highly sulfated regions of their HS polysaccharide chains.
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