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Bryn Marie Reimer on Muck Rack

Bryn Marie Reimer

As seen in: Nature
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Articles

Fragment-based discovery enables direct targeting of the melanoma oncogene MITF - Nature Communications

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By Jürgen Hinrichs Verified, Bryn Marie Reimer, Markus Wartmann, Marc Altorfer, Rainer Wilcken, Anna Vulpetti, Deborah Castelletti, Nicolas Pautrieux, Frederic Baysang
| Nature Verified
Abstract Despite the improvement of therapeutic options, melanoma patients with advanced metastatic disease are still in high need of durable treatments. Analysis of clinical data from patients receiving targeted and/or immunotherapy, along with genetic and functional studies in preclinical melanoma models, demonstrates the key role of the microphthalmia-associated transcription factor (MITF) throughout disease progression, and provides a solid rationale for its therapeutic inhibition.
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CovCysPredictor: Predicting Selective Covalently Modifiable Cysteines Using Protein Structure and Interpretable Machine Learning

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By Ernest Awoonor-Williams, Andrei A. Golosov, Viktor Hornak, Bryn Marie Reimer
| dx.doi.org
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