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Buer Ha

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Articles

Efficient in vivo cytosine base editing using virus-like particles with uracil DNA glycosylase inhibition

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By Junjie Zhu, Lin Ding, Kai-Ming Liu, Xingyu Zhu, Jifang Li, Bao-Qing Gao, Xujiao Zhou, Chengfang Liu, Jia Wei, Wenchao Xu, Lingyun Kong, Jing Cynthia Wu, Xiaodun Mou, Bei Yang, Lijie Wang, Jiaxu Hong, Jia Chen, Buer Ha, Shuangyu Ma
| Nature Verified
Abstract Virus-like particles (VLPs) are promising for delivering genome editors, yet the in vivo in vivo efficacy of VLP-mediated cytosine base editing remains limited. Here we identified insufficient inhibition of uracil DNA glycosylases as the underlying mechanism of low cytosine base editor (CBE) editing efficiencies in vivo.
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