Burcu Tepekule

Our model mainly focuses on the mechanisms governing the GC reactions in the GALT inductive sites, and the main route of antigen transport to these sites is carried out by M cells which appear shortly before weaning primarily due to the decreasing concentrations of maternal steroids in the breastmilk [33,35]. In the absence of quantitative data, we propose using the concentration of mSIgA as an indirect measure of maternal steroid levels.

Abstract Despite the increasing burden of antibiotic resistance and persistence, current approaches to eradicate nasal pathobionts such as Staphylococcus aureus and Streptococcus pneumoniae are based on the use of antibacterial agents. An alternative approach is the artificial inoculation of commensal bacteria, i.e., probiotic treatment, which is supported by the increasing evidence for commensal-mediated inhibition of pathogens.

Abstract To achieve immune and microbial homeostasis during adulthood, the developing immune system must learn to identify which microbes to tolerate and which to defend against. How such 'immune education' unfolds remains a major knowledge gap. We address this gap by synthesizing existing literature to develop a mechanistic mathematical model representing the interplay between gut ecology and adaptive immunity in early life.