Buuvee Bayarkhangai

Abstract Chronic diabetic wounds present a critical clinical challenge due to persistent inflammation and compromised healing. Here, we report a sprayable nanozyme hydrogel that epigenetically remodels macrophages (Mφ) to suppress inflammation and coordinate regeneration. Ultrasmall copper-based nanozymes (CuNZ, ~4 nm) synthesized via an eco-friendly one-pot method demonstrated potent multi-radical scavenging activity.

Graphical Abstract Nuclear Mechanosensing Article number 2403409 highlights a nuclear mechanosensing mechanism of macrophages during M2 polarization. Dong-Hwee Kim, Jung-Hwan Lee, Jeongeun Hyun, Hae-Won Kim, and co-workers demonstrate how cells coordinate matrix rigidity and biochemical signals through altered nuclear tension and deformation and the chromatin accessibility of target genes. Their findings offer new insights into macrophage mechanobiology and therapeutic modulation.

1 Introduction Macrophages, as versatile immune cells, exhibit a broad range of phenotypes that encompass both pro-inflammatory and anti-inflammatory states in response to cues from the microenvironment.[1] While macrophages display diverse phenotypes with high heterogeneity in various tissues,[2] they are commonly categorized into classically activated (M1) and alternatively activated (M2) subtypes.