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Author Correction: Single-cell multi-omic detection of DNA methylation and histone modifications reconstructs the dynamics of epigenomic maintenance - Nature Methods
Correction to: Nature Methods https://doi.org/10.1038/s41592-025-02839-4, published online 2 October 2025. In the version of this article initially published, there was a figure referencing error in the “Nucleosome occupancy direct DNA methylation maintenance following DNA replication” section due to changes during revisions. The text “These dynamics are also visible upon normalization of CpG methylation (Fig.
Author Correction: Single-cell multi-omic detection of DNA methylation and histone modifications reconstructs the dynamics of epigenomic maintenance - Nature Methods
Correction to: Nature Methods https://doi.org/10.1038/s41592-025-02847-4, published online 25 September 2025. In the version of the article initially published, in the “Chromatin modification” key in Fig. 2d, both green and purple were listed as “H3K36me3”. This has now been corrected so that green is “H3K36me3” and purple is “H3K9me3”. This correction has been made to the HTML and PDF versions of the article.
Single-cell multi-omic detection of DNA methylation and histone modifications reconstructs the dynamics of epigenomic maintenance - Nature Methods
Abstract DNA methylation and histone modifications encode epigenetic information. Recently, major progress was made to measure either mark at a single-cell resolution; however, a method for simultaneous detection is lacking, preventing study of their interactions. Here, to bridge this gap, we developed scEpi2-seq. Our technique provides a readout of histone modifications and DNA methylation at the single-cell and single-molecule level.
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