Bychkov M.L on Muck Rack

Bychkov M.L

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Articles

Deciphering the roadmap of in vivo reprogramming toward pluripotency

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By Dafni Chondronasiou, Elena Meléndez, Cian J. Lynch, Bychkov M.L
| Stem Cell Reports Verified
Introduction The ability to manipulate cell fate in vitro has revolutionized regenerative medicine. The most striking breakthrough in the field occurred when Yamanaka first demonstrated the ability of adult differentiated cells to give rise to pluripotent cells (induced pluripotent stem cells [iPSCs]) upon the simultaneous expression of four transcriptional factors, OCT4, SOX2, KLF4, and MYC (OSKM) ( ).
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