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Articles

Biotin mitigates the development of manganese-induced, Parkinson’s disease-related neurotoxicity in Drosophila and human neurons

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By Yajuan Rui, Yunjia Lai, Bypassing senescenceBy, Annalisa M. VanHook Verified
| Science Magazine Verified
Editor’s summary Manganese is essential for various cell functions, but chronic exposure causes a neurodegenerative condition with symptoms resembling Parkinson’s disease. Lai et al. developed an adult fly model of manganese-induced parkinsonism and found that altered metabolism of biotin (also known as vitamin B7) mediated the metal’s neurotoxicity.
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HIV-1 Vpu and SARS-CoV-2 ORF3a proteins disrupt STING-mediated activation of antiviral NF-κB signaling

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By Yajuan Rui, Yunjia Lai, Bypassing senescenceBy, Annalisa M. VanHook Verified
| Science Magazine Verified
Editor’s summary Interferon signaling induced by activation of the stimulator of interferon genes (STING) pathway is a potent weapon in the cellular antiviral arsenal. In addition to stimulating interferon signaling, STING also activates the transcription factor nuclear factor κB (NF-κB). Rui et al. found that STING-mediated activation of NF-κB inhibited the replication of DNA and RNA viruses in cultured cells independently of interferon induction.
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Bypassing senescence

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By Yajuan Rui, Yunjia Lai, Bypassing senescenceBy, Annalisa M. VanHook Verified
| Science Magazine Verified
Abstract A metabolic switch enables hepatocytes in damaged livers to escape senescence and form tumors. SIGN UP FOR THE AWARD-WINNING SCIENCEADVISER NEWSLETTER The latest news, commentary, and research, free to your inbox daily The accumulation of fat in the liver causes chronic inflammation that leads to metabolic dysfunction–associated steatohepatitis (MASH). This condition results in liver dysfunction, fibrosis, and an increased risk of developing hepatocellular carcinoma (HCC).
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