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C. Denby Wilkes on Muck Rack

C. Denby Wilkes

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Compact Origins and Where to Find Them: ORC's Guide to Genome‐Wide Licensing

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By Christian Speck, Luitpold Maximilian Reuter, C. Denby Wilkes
| Wiley Online Library Verified
1 Introduction The duplication of DNA must be of the highest quality to preserve genetic information. Mistakes during this process lead to the accumulation of mutations, ultimately promoting disease and aging. DNA replication is a two-step process, starting with the loading of the replicative helicase at a single (bacteria) [1], hundreds (yeast) [2], or thousands (human) [3] of replication origins followed by activation of the helicase.
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