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Cardiovascular Outcomes With Dupilumab Versus Omalizumab in Severe Asthma
To the Editor, Severe asthma is associated with increased cardiovascular morbidity, but comparative cardiovascular safety data across biologic agents remain limited [1, 2]. We therefore emulated a target trial comparing major adverse cardiovascular events among patients initiating dupilumab or omalizumab. We used the TriNetX U.S. Collaborative Network from January 1, 2019, to December 31, 2025.
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