C. Marcelo Aldaz

1 Introduction In 2013 scientists at the Wellcome Trust Sanger Institute introduced the concept of “mutational signatures”, bioinformatically extracted from sequences of cancers of many subtypes, and proposed that the single base pair substitution signatures (SBSs) result from processes driving development of these cancers [1, 2] and that somatic mutations in cancer genomes would exhibit signatures of the mutational processes operating in the developing cancers; ~5 million mutations were...