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Articles by Caide Lu
Explainable machine learning identifies small high-performance gene signatures from full transcriptomes in human liver preservation cohorts
Abstract Transcriptomic studies of liver preservation and ischemia–reperfusion injury (IRI) often report large gene lists that are difficult to translate into deployable diagnostic tools. Genome-wide profiling remains impractical within organ procurement timelines, where decisions must be made rapidly and assay infrastructure is limited.
Single-cell transcriptomic profiling reveals cellular stress responses to hypothermic preservation in liver-on-chip model
Abstract Cold preservation is a critical logistical step in liver transplantation but induces ischemia–reperfusion injury (IRI), a key driver of early graft dysfunction. While bulk tissue assays capture global damage, they obscure the cell-type-specific transcriptional programs engaged during hypothermic storage.
Circular RNA Hsa_circ_0062403 Acts as a Potential Prognostic Biomarker for Early Recurrence of Hepatocellular Carcinoma
Back to Journals » International Journal of General Medicine » Volume 19 Original Research Oncology Authors Yu X, Shan Y, Lu C, Mao S Received 27 March 2026 Accepted for publication 4 June 2026 Published 12 June 2026 Volume 2026:19 612522 DOI https://doi.org/10.2147/IJGM.S612522 Checked for plagiarism Yes Review by Single anonymous peer review Peer reviewer comments 3 Editor who approved publication: Professor Hyam Leffert Xi Yu, Yuying Shan, Caide Lu, Shuqi Mao Department of...
Frontiers | Association of HLA-DQA1*06:01 and DPB1*05:01:01G alleles with susceptibility to end-stage liver disease with HBV infection in liver transplant recipients from the Zhejiang Han population, China
1 Introduction Liver disease causes two million deaths annually worldwide and accounts for 4% of all deaths (1). The concept of end-stage liver disease (ESLD) was first introduced in the 1980s, which refers to the end stage of chronic liver disease, with advanced liver injury, dysfunction, and decompensation, regardless of the etiology (2, 3). The main clinical feature of ESLD is the liver’s inability to meet the body’s physiological needs.
Development and validation of a novel preoperative clinical model for predicting lymph node metastasis in perihilar cholangiocarcinoma - BMC Cancer
One hundred and sixty pCCA patients (ninety-six in the training cohort and sixty-four in the validation cohort) were included in our present research. Of the 160 patients, 77 (48.1%) patients had LNM (50 (50/96, 52.1%) in the training cohort and 27 (27/64, 42.2%) in the validation cohort) on pathologic examination after surgical resection. The median time of follow-up was 24 (range: 3-150) months, 112 patients died, and 48 patients survived up to the current follow-up time point.
Prognostic and immune infiltration analysis of transaldolas
Back to Journals » International Journal of General Medicine » Volume 16 Original Research Oncology Authors Cen K , Lu C Received 6 July 2023 Accepted for publication 10 November 2023 Published 8 December 2023 Volume 2023:16 Pages 5779—5788 DOI https://doi.org/10.2147/IJGM.S425490 Checked for plagiarism Yes Review by Single anonymous peer review Peer reviewer comments 2 Editor who approved publication: Dr Scott Fraser Kedan Cen, Caide Lu Department of Hepatopancreatobiliary Surgery, The...
Undifferentiated Pancreatic Carcinomas, Clinical Features and Therapeutic Options: What We Know
Open AccessReview by Joseph Mugaanyi 1,2, Changjiang Lu 2, Jing Huang 2 and Caide Lu 2,* 1 School of Medicine, Ningbo University, Ningbo 315211, China 2 Department of Hepato-Pancreato-Billiary Surgery, Ningbo Medical Center Li Huili Hospital, Ningbo University, Ningbo 315211, China * Author to whom correspondence should be addressed.
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