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The efficient synthesis of three-membered rings via photo- and electrochemical strategies Three-membered rings, such as epoxides, aziridines, oxaziridines, cyclopropenes, vinyloxaziridines, and azirines, are recognized as crucial pharmacophores and building blocks in organic chemistry and drug discovery.
Highlights • Neddylation is essential for β-catenin degradation • β-TrCP2 is associated with neddylation and destruction of β-catenin • GSK3 and APC are not required for β-catenin neddylation • GSK3 and APC are essential for degradation of neddylated β-catenin Summary β-Catenin is a central component in the Wnt signaling pathway; its degradation has been tightly connected to ubiquitylation, but it is rarely examined by loss-of-function assays.
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