Caizhelin An on Muck Rack

Caizhelin An

As seen in: Dialnet - Universidad de La Rioja
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Matrix stiffening induces hepatocyte functional impairment and DNA damage via the Piezo1‒ERK1/2 signaling pathway

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By Yanan Fan, Zhihui Wang, Caizhelin An
| Dialnet - Universidad de La Rioja
Hepatocytes are the primary functional cells in the liver, and the malignant transformation of hepatocytes significantly contributes to hepatocellular carcinoma (HCC) progression. Liver fibrosis and cirrhosis caused by extracellular matrix (ECM) remodeling during liver lesions is a pivotal driver of HCC. However, the impact of matrix stiffness on hepatocytes and the underlying molecular mechanisms are not fully understood.
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