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Caleb Emmanuel Santiago on Muck Rack

Caleb Emmanuel Santiago

As seen in: Nature
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Articles

DNA methylation modulation by 5-Azacytidine regulates EMT markers and reduces invasiveness in docetaxel-resistant prostate cancer cells

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By Carmen Ortiz-Sánchez, Gabriela Castro, Valerie Rodriguez, Caleb Emmanuel Santiago, Lenin Godoy, Donghoon Yoon, Kosj Yamoah, Jong Y. Park, Shakira Abad, Solimar Esteves-Vega, Stephanie Montalvo, Rodniel Avilés, Ralphdy Vergne, Gustavo Alayón, Gilberto Ruiz-Deyá
| Nature Verified
Abstract Metastatic castration-resistant prostate cancer (mCRPC) is associated with poor prognosis and high mortality, largely due to androgen and chemotherapy resistance. This study investigated whether global DNA hypomethylation induced through DNMT1 inhibition could reduce invasion and motility in docetaxel-resistant (DR) prostate cancer (PCa).
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