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Articles by Caleb Stratton
Saturation mutagenesis enables RAD51D clinical variant interpretation and identifies distinct biochemical functions
Abstract The tumor suppressor RAD51D is essential for homologous recombination (HR). Pathogenic variants in RAD51D are associated with breast and ovarian cancers. However, most clinical missense variants are of uncertain significance. Here, we report a multiplex assay of variant effect to test 6,888 RAD51D coding variants for loss-of-function.
Structural insight into how RAD51 paralog exchange regulates RAD51 filament formation
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Abstract Homologous recombination (HR) repairs DNA double-strand breaks and stabilizes stressed replication forks, and HR deficiency promotes genome instability and cancer. HR requires assembly of RAD51 nucleoprotein filaments on single-stranded DNA (ssDNA), a process regulated by the human RAD51 paralogs RAD51C, XRCC3, RAD51D and XRCC2.
By Yashpal Rawal, YoungHo Kwon, Lijia Jia, Eliza A Ruben, Jae-Hoon Ji, Lijuan Guo, Caleb Stratton, Digant Nayak, Miriam Tovar, Qingming Fang, Mohd Azrin Jamalruddin, Shuo Zhou, Sahiti Kuppa, Shahrez Syed, Angela M. Jasper, Jeffrey N. Katz, Cody M. Rogers, HARDEEP KAUR, Weixing Zhao, Eloïse Dray, Fang Zhang, Alexander Taylor, Sandeep Burma, Manjeet K. Rao, David S. Libich, Robert A. Hromas, Alexander V. Mazin, Maria Jasin, Daohong Zhou, Kara A. Bernstein, Eric Greene, Elizabeth V. Wasmuth, Patrick Sung Verified, Shaun K Olsen, Lorena Samentar, Svetla Stoilova- McPhie
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Nature
Verified
A penicillin-binding protein inhibitor series to target drug-resistant Neisseria gonorrhoeae
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Abstract Emerging multidrug-resistant Neisseria gonorrhoeae strains possessing altered penA alleles (encoding penicillin-binding protein 2, PBP2) threaten the utility of ceftriaxone, the last remaining outpatient antibiotic for gonorrhoea treatment, posing a global health emergency. Here we report a benzoxaborinine-based penicillin-binding protein inhibitor series (boro-PBPi) developed to address penA-mediated ceftriaxone resistance.
By Tsuyoshi Uehara, Brittany Miller, Lindsay M. Avery, Steven Boyd, Mitchell Edwards, Susan Hart, Nathan J. Line, Cullen L. Myers, Annie Stevenson, Kyoko Uehara, Fan Yi, Bibo Wang, Zhenwu Liu, Mingyue Wang, Zhichao Zhao, Haiyan Zhao, Caleb Stratton, Christopher Davies, Rok Tkavc, Ann E. Jerse, Christopher Burns, Denis Daigle, Stephen Condon, Allison L. Zulli, Cassandra L. Chatwin, Guo-Hua Chu, Anthony S. Drager, Gopinath Rongala, Xinming Zhou, Sandeepchowdary Bala, Daniel C. Pevear
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Nature
Verified
Cryo-EM structures of UBA6 reveal mechanisms of E1–E2 specificity and dual FAT10/ubiquitin thioester transfer - Nature Communications
Abstract UBA1 and UBA6 define parallel ubiquitin (Ub) activation systems that perform non-overlapping roles in Ub and ubiquitin-like protein (Ubl) signaling. Whereas UBA1 supports the canonical Ub pathway, UBA6 also activates the Ubl FAT10, linking Ub signaling to immune-regulated proteostasis. In addition to selective Ub/Ubl activation, UBA1 and UBA6 engage distinct sets of E2s, yet how these enzymes achieve selective E2 engagement has remained unclear.
Resolving inflammation: Could it prevent memory loss in Down syndrome and Alzheimer's?
Dr. Eric D. Hamlett, assistant professor in the Department of Pathology and Laboratory Medicine at the Medical University of South Carolina, is lead author on the Glia article. Credit: Sarah Pack, Medical University of South Carolina Individuals with Down syndrome are at a much greater risk of developing Alzheimer's disease, with inflammation of the brain starting early in life and the risk of Alzheimer's reaching nearly 80% by the age of 60. The root cause of Alzheimer's disease is unknown.
Chemicals between us: Surprising effects of oxytocin on cocaine addiction
The figure shows brain activation to pictures related to cocaine use in male and female cocaine users with a history of childhood trauma. The green arrow points to the amygdala. When males received placebo, the amygdala was very responsive to cocaine cues, but on oxytocin, this response diminished. The opposite was true for female cocaine users. Credit: Image abridged from figure in Joseph et al Psychopharmacology article (DOI: 10.1007/s00213-019-05360-7), with permission of Springer Nature.
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